Charlotte's Web is a fantastic novel; I have read this two or three times. A little girl named Fern puts forth all her efforts to save and take care of a pig named that her dad just wants gone. The novel includes a spider named Charlotte who is a very motherly and encouraging friend to Wilbur. This story teaches students about true friendship and devotion to one another.
For this novel, I would read it in a fourth or fifth grade classroom, and have my students throughout our reading make notes about the characters, then at the end of our reading I would have them either fill out a graphic organizer with the plot (beginning, climax, and ending) or have discussion questions in groups about the theme, plot, characters, etc.